Impact of gender and age on the association of the BUD13-ZNF259 rs964184 polymorphism with coronary heart disease.

ABSTRACT:

Objective

Coronary heart disease (CHD) is the most common cause of death worldwide. This study aimed to validate the association of the rs964184 polymorphism with the CHD risk and included 874 CHD patients and 776 controls.

Methods

rs964184 polymorphism genotyping was performed using Tm-shift polymerase chain reaction.

Results

A strong association of the rs964184 polymorphism with CHD was found (genotype: X²=14.365, p=0.001; allele: X²=14.191, p=1.67x10^-4; power=0.965). Gender analysis revealed a significant association only in males (genotype: X²=12.387, p=0.002; allele: X²=12.404, p=4.32x10^-4; OR=1.467, 95% CI=1.185-1.817, power=0.945). Age and gender analyses revealed significant associations of the

SUBMITTER: Xu X 

PROVIDER: S-EPMC5864789 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature