A Poroelastic Model of a Fibrous-Porous Tissue Engineering Scaffold.

ABSTRACT: Tissue engineering scaffolds are used in conjunction with stem cells for the treatment of various diseases. A number of factors provided by the scaffolds affect the differentiation of stem cells. Mechanical cues that are part of the natural cellular microenvironment can both accelerate the differentiation toward particular cell lineages or induce differentiation to an alternative cell fate. Among such factors, there are externally applied strains and mechanical (stiffness and relaxation time) properties of the extracellular matrix. Here, the mechanics of a fibrous-porous scaffold is studied by applying a coordinated modeling and experimental approach. A force relaxation experiment is used, and a poroelastic model associates the relaxation process with the fluid diffusion through the fibrou

SUBMITTER: Yuan D 

PROVIDER: S-EPMC5864912 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature