Outcome of Critically ill Patients Undergoing Mandatory Insulin Therapy Compared to Usual Care Insulin Therapy: Protocol for a Pilot Randomized Controlled Trial.

ABSTRACT: BACKGROUND:Observational and interventional studies in patients with both acute medical conditions and long-standing diabetes have shown that improved blood glucose control confers a survival advantage or reduces complication rates. Policies of "tight" glycaemic control were rapidly adopted by many general intensive care units (ICUs) worldwide in the mid 00's, even though the results of the studies were not generalizable to mixed medical/surgical ICUs with different intravenous feeding policies. OBJECTIVE:The primary objective of the study is to assess the safety of mandatory insulin infusion in critically ill patients in a general ICU setting. METHODS:This protocol summarizes the rationale and design of a randomized, controlled, single-center trial investigating the effect of mandatory in

SUBMITTER: Watkinson PJ 

PROVIDER: S-EPMC5865000 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature