Screening and Genomic Characterization of Filamentous Hemagglutinin-Deficient Bordetella pertussis.

ABSTRACT: Despite high vaccine coverage, pertussis cases in the United States have increased over the last decade. Growing evidence suggests that disease resurgence results, in part, from genetic divergence of circulating strain populations away from vaccine references. The United States employs acellular vaccines exclusively, and current Bordetella pertussis isolates are predominantly deficient in at least one immunogen, pertactin (Prn). First detected in the United States retrospectively in a 1994 isolate, the rapid spread of Prn deficiency is likely vaccine driven, raising concerns about whether other acellular vaccine immunogens experience similar pressures, as further antigenic changes could potentially threaten vaccine efficacy. We developed an electrochemiluminescent antibody capture a

SUBMITTER: Weigand MR 

PROVIDER: S-EPMC5865017 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature