Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians.

ABSTRACT: Urine haptoglobin (uHP) level prospectively predicts diabetic kidney disease (DKD) progression. Here, we aim to identify genetic determinants of uHP level and evaluate association with renal function in East Asians (EA) with type 2 diabetes (T2D). Genome-wide association study (GWAS) among 805 [236 Chinese (discovery) and 569 (57 Malay and 512 Chinese) (validation)] found that rs75444904/kgp16506790 variant was robustly associated with uHP level (MetaP = 1.21 × 10^-60). rs75444904 correlates well with plasma HP protein levels and multimerization in EA but was not in perfect LD (r² = 0.911 in Chinese, r² = 0.536 in Malay) and is monomorphic in Europeans (1000 G data). Conditional probability analysis indicated weakening of effects but residual significant ass

SUBMITTER: Gurung RL 

PROVIDER: S-EPMC5865208 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature