Long-term effect of critical illness after severe paediatric burn injury on cardiac function in adolescent survivors: an observational study.

ABSTRACT:

Background

Sepsis, trauma, and burn injury acutely depress systolic and diastolic cardiac function; data on long-term cardiac sequelae of pediatric critical illness are sparse. This study evaluated long-term systolic and diastolic function, myocardial fibrosis, and exercise tolerance in survivors of severe pediatric burn injury.

Methods

Subjects at least 5 years after severe burn (post-burn:PB) and age-matched healthy controls (HC) underwent echocardiography to quantify systolic function (ejection fraction[EF%]), diastolic function (E/e'), and myocardial fibrosis (calibrated integrated backscatter) of the left ventricle. Exercise tolerance was quantified by oxygen consumption (VO₂) and heart rate at rest and peak exercise. Demographic information, clinical data, a

SUBMITTER: Hundeshagen G 

PROVIDER: S-EPMC5865217 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature