Acidosis and acute kidney injury in severe malaria.

ABSTRACT:

Background

In severe falciparum malaria metabolic acidosis and acute kidney injury (AKI) are independent predictors of a fatal outcome in all age groups. The relationship between plasma acids, urine acids and renal function was investigated in adult patients with acute falciparum malaria.

Methods

Plasma and urinary acids which previously showed increased concentrations in proportion to disease severity in patients with severe falciparum malaria were quantified. Patients with uncomplicated malaria, sepsis and healthy volunteers served as comparator groups. Multiple regression and multivariate analysis were used to assess the relationship between organic acid concentrations and clinical syndromes, in particular AKI.

Results

Patients with severe malaria (n = 90), uncompl

SUBMITTER: Sriboonvorakul N 

PROVIDER: S-EPMC5865348 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature