High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production.

ABSTRACT:

Background

Changes in hygiene and dietary habits, including increased consumption of foods high in fat, simple sugars, and salt that are known to impact the composition and function of the intestinal microbiota, may explain the increase in prevalence of chronic inflammatory diseases. High salt consumption has been shown to worsen autoimmune encephalomyelitis and colitis in mouse models through p38/MAPK signaling pathway. However, the effect of high salt diet (HSD) on gut microbiota and on intestinal immune homeostasis, and their roles in determining vulnerability to intestinal inflammatory stimuli are unknown. Here, we investigate the role of gut microbiota alterations induced by HSD on the severity of murine experimental colitis.

Results

Compared to control diet, HSD altere

SUBMITTER: Miranda PM 

PROVIDER: S-EPMC5865374 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature