A novel role for osteopontin in macrophage-mediated amyloid-β clearance in Alzheimer's models.

ABSTRACT: Osteopontin (OPN), a matricellular immunomodulatory cytokine highly expressed by myelomonocytic cells, is known to regulate immune cell migration, communication, and response to brain injury. Enhanced cerebral recruitment of monocytes achieved through glatiramer acetate (GA) immunization or peripheral blood enrichment with bone marrow (BM)-derived CD115⁺ monocytes (Mo^BM) curbs amyloid β-protein (Aβ) neuropathology and preserves cognitive function in murine models of Alzheimer's disease (ADtg mice). To elucidate the beneficial mechanisms of these immunomodulatory approaches in AD, we focused on the potential role of OPN in macrophage-mediated Aβ clearance. Here, we found extensive OPN upregulation along with reduction of vascular and parenchymal Aβ burden in cortices a

SUBMITTER: Rentsendorj A 

PROVIDER: S-EPMC5865478 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature