Impact of steatosis and inflammation definitions on the performance of NASH tests.

ABSTRACT:

Background and aim

One of the unmet needs in subjects with metabolic risks is the prediction of metabolic liver disease by noninvasive tests. The construction of performant tests is dependent on the appropriateness of the histological reference definition. The aim of this study was to analyze the limitations of similar European (Fatty Liver Inhibition of Progression) and USA (Clinical-Research-Network) standard definitions and their impact on the construction of tests.

Methods

We hypothesized that a simpler histological definition of non-alcoholo steato-hepatitis (NASH), which does not require the presence of steatosis and the presence of both lobular inflammation and ballooning, should improve the concordance rates with previously validated blood tests. We reviewed the land

SUBMITTER: Poynard T 

PROVIDER: S-EPMC5865485 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature