Subcortical Brain and Behavior Phenotypes Differentiate Infants With Autism Versus Language Delay.

ABSTRACT:

Background

Younger siblings of children with autism spectrum disorder (ASD) are themselves at increased risk for ASD and other developmental concerns. It is unclear if infants who display developmental concerns, but are unaffected by ASD, share similar or dissimilar behavioral and brain phenotypes to infants with ASD. Most individuals with ASD exhibit heterogeneous difficulties with language, and their receptive-expressive language profiles are often atypical. Yet, little is known about the neurobiology that contributes to these language difficulties.

Methods

In this study, we used behavioral assessments and structural magnetic resonance imaging to investigate early brain structures and associations with later language skills. High-risk infants who were later diagnosed with

SUBMITTER: Swanson MR 

PROVIDER: S-EPMC5865637 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature