Genetic variation of CXCR4 and risk of coronary artery disease: epidemiological study and functional validation of CRISPR/Cas9 system.

ABSTRACT: Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, while coronary artery disease (CAD) account for a large part of CVDs. Vascular CXCR4 could limit atherosclerosis by maintaining arterial integrity. Here, we conducted a population-based, case-control study to evaluate the associations of common genetic variation within the CXCR4 gene (rs2228014, rs117600832, rs2471859, and rs2322864) with CAD risk in a Chinese population. We found that CXCR4 rs2228014 was significantly associated with 1.29-fold increased risk of CAD (A vs G: OR = 1.29; 95% CI = 1.07-1.55; P = 0.007). The subjects with genotype AA (OR = 1.98; 95% CI = 1.03-3.81; P = 0.041) and AG (OR = 1.27; 95% CI = 1.02-1.58; P = 0.030) have higher risk of CAD, compared with those with genotyp

SUBMITTER: Runmin G 

PROVIDER: S-EPMC5865654 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature