Urinary cell-free nucleic acid IQGAP3: a new non-invasive diagnostic marker for bladder cancer.

ABSTRACT:

Background

There is growing interest in developing new non-invasive diagnostic tools for bladder cancer (BC) that have better sensitivity and specificity than cystoscopy and cytology. This study examined the value of urinary cell-free nucleic acid (NA) as a diagnostic marker for BC.

Material and methods

A total of 81 patients (74 BC and 7 normal controls) were used for a tissue set, and 212 patients (92 BC and 120 normal controls) were used as a urine set. Expression of tissue mRNA and urinary cell-free NAs was then examined.

Results

Four candidate genes were top-ranked in the tissue microarray. Expression levels of two of these (IQGAP3 and TOP2A) in BC tissue and urine samples from BC patients were significantly higher than those in samples from the control groups. B

SUBMITTER: Kim WT 

PROVIDER: S-EPMC5865675 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature