Long noncoding RNA ANRIL as a novel biomarker of lymph node metastasis and prognosis in human cancer: a meta-analysis.

ABSTRACT: Dysregulation of the long noncoding RNA antisense noncoding RNA in the INK4 locus (ANRIL) has been reported in various solid tumors. We performed a synthetic analysis to clarify the clinical value of ANRIL as a prognostic indicator in malignant tumors. Article collection was conducted using several electronic databases, including PubMed, Web of Science, Medline, OVID and Embase (up to July 14 2017). Thirteen original studies and 1172 total patients were included in the meta-analysis. There was a significant positive association between the high expression level of ANRIL and lymph node metastasis (OR = 4.77, 95% CI: 2.30-9.91, P < 0.001) by a random effects model (I² = 73.2, P = 0.001) and negative association with poor grade cancer (OR = 3.44, 95% CI: 1.68-7.08) by

SUBMITTER: Wang H 

PROVIDER: S-EPMC5865693 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature