Clinicopathological and prognostic significance of Twist overexpression in NSCLC.

ABSTRACT: Several studies were conducted to explore the prognostic significance of Twist in non-small cell lung cancer (NSCLC), however, contradictory results in different studies were reported. To this end, we presented a systematic review aiming to summarize the prognostic significance of Twist in patients with NSCLC. 5 studies involving a total of 572 patients were identified. The result indicated that high Twist expression was significantly associated with a worse overall survival (OS) (hazard ratio (HR) = 2.19, 95% confidence interval (95% CI) = 1.64-2.94, p < 0.001; I² = 0.0%, fixed effect), recurrence-free survival (RFS) (HR = 2.476, 95% CI = 1.728-3.547, p < 0.001; I² = 0.0%, fixed effect) and lymph node or other metastasis (odds rate (OR) = 0.419, 95% CI

SUBMITTER: Li M 

PROVIDER: S-EPMC5865696 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature