Microarray and bioinformatics analyses of gene expression profiles in BALB/c murine macrophage polarization.

ABSTRACT: Macrophages possess the hallmark feature of plasticity, allowing them to undergo a dynamic transition between M1 and M2 polarized phenotypes. The aim of the present study was to screen for differentially-expressed genes (DEGs) that were associated with BALB/c murine macrophage polarization. The transcription profiles of three M1 and three M2 samples were obtained using microarray analysis. Based on the threshold of fold‑change >2.0 and P‑value <0.05, a total of 1,253 DEGs were identified, of which 696 were upregulated and 557 downregulated in M1 macrophages compared with M2 macrophages. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. A gene‑gene interaction network of the DEGs was constructed using the Search Tool f

SUBMITTER: Jiang L 

PROVIDER: S-EPMC5865869 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature