Effects of nuclear factor‑κB on the uptake of 131iodine and apoptosis of thyroid carcinoma cells.

ABSTRACT: Thyroid carcinoma is primarily treated by surgery combined with radioactive 131iodine (131I) treatment; however, certain patients exhibit resistance to 131I treatment. Previous research indicated that nuclear factor‑κB (NF‑κB) was associated with resistance to 131I in cancer cells. The present study aimed to investigate the effects of NF‑κB on 131I uptake and apoptosis in thyroid carcinoma cells. TPC‑1 and BCPAP cell lines were employed as research models in the present study, and the expression of NF‑κB was inhibited by RNA interference (RNAi). The ability of TPC‑1 and BCPAP cells to uptake 131I was measured and the cell viability was detected by an MTT assay. Finally, the expression of the apoptosis‑associated proteins X‑linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptos

SUBMITTER: Chen F 

PROVIDER: S-EPMC5865955 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature