Oriented chiral water wires in artificial transmembrane channels.

ABSTRACT: Aquaporins (AQPs) feature highly selective water transport through cell membranes, where the dipolar orientation of structured water wires spanning the AQP pore is of considerable importance for the selective translocation of water over ions. We recently discovered that water permeability through artificial water channels formed by stacked imidazole I-quartet superstructures increases when the channel water molecules are highly organized. Correlating water structure with molecular transport is essential for understanding the underlying mechanisms of (fast) water translocation and channel selectivity. Chirality adds another factor enabling unique dipolar oriented water structures. We show that water molecules exhibit a dipolar oriented wire structure within chiral I-quartet water channels b

SUBMITTER: Kocsis I 

PROVIDER: S-EPMC5866074 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature