Identification of Herpes Zoster-Associated Temporal Arteritis Among Cases of Giant Cell Arteritis.

ABSTRACT: PURPOSE:To examine whether herpes zoster antigen (also called varicella-zoster virus antigen) was detectable in temporal artery biopsies taken from individuals with giant cell arteritis (GCA). DESIGN:Retrospective comparative case series. METHODS:Sections of formalin-fixed paraffin-embedded temporal arteries were examined first by hematoxylin-eosin (H&E) staining to establish the diagnosis of GCA. Adjacent sections of the same biopsy were then examined by immunohistochemistry, using 2 different monoclonal antibodies against a major antigen of varicella-zoster virus called gE. Pathologic specimens were obtained from patients cared for at the University of Iowa and Washington University in St. Louis ophthalmology clinics. RESULTS:The study included biopsies from 25 patients with symptoms of

SUBMITTER: Buckingham EM 

PROVIDER: S-EPMC5866091 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature