A critical role for donor-derived IL-22 in cutaneous chronic GVHD.

ABSTRACT: Graft-versus-host disease (GVHD) is the major cause of nonrelapse morbidity and mortality after allogeneic stem cell transplantation (allo-SCT). Prevention and treatment of GVHD remain inadequate and commonly lead to end-organ dysfunction and opportunistic infection. The role of interleukin (IL)-17 and IL-22 in GVHD remains uncertain, due to an apparent lack of lineage fidelity and variable and contextually determined protective and pathogenic effects. We demonstrate that donor T cell-derived IL-22 significantly exacerbates cutaneous chronic GVHD and that IL-22 is produced by highly inflammatory donor CD4⁺ T cells posttransplantation. IL-22 and IL-17A derive from both independent and overlapping lineages, defined as T helper (Th)22 and IL-22⁺ Th17 cells. Donor Th22 an

SUBMITTER: Gartlan KH 

PROVIDER: S-EPMC5866168 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature