Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.

ABSTRACT:

Objective

Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss.

Methods

Forty people with obesity (BMI = 37.9 ± 4.3 kg/m² ) were randomized to weight maintenance (n = 14) or weight loss (n = 19). Subjects were studied before and after 6 months of weight maintenance and before and after 5%, 11%, and 16% weight loss. A hyperinsulinemic-euglycemic clamp procedure in conjunction with [6,6-² H₂ ]glucose tracer infusion was used to assess glucose kinetics.

Results

At baseline, fasting [LAC] correlated

SUBMITTER: Chondronikola M 

PROVIDER: S-EPMC5866193 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature