Impact of cancer treatment on risk of infertility and diminished ovarian reserve in women with polycystic ovary syndrome.

ABSTRACT: OBJECTIVE:To compare markers of fertility and ovarian reserve between cancer survivors and cancer-free women with and without polycystic ovary syndrome (PCOS). DESIGN:Furthering Understanding of Cancer, Health, and Survivorship in Adult (FUCHSIA) Women's Study-a population-based cohort study. SETTING:Not applicable. PATIENT(S):Female cancer survivors (n = 1,090) aged 22-45 years, diagnosed between ages 20 and 35 years, and at least 2 years after diagnosis; 369 participated in a clinic visit. Three hundred seventy-four reproductive-aged women without cancer also completed a clinic visit. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Infertility, time to first pregnancy after cancer diagnosis, and measures of ovarian reserve (antimüllerian hormone [AMH] and antral follicle count [AFC]). RESU

SUBMITTER: Shandley LM 

PROVIDER: S-EPMC5866226 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature