A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux.

ABSTRACT: Endogenous circadian rhythms are thought to modulate responses to external factors, but mechanisms that confer time-of-day differences in organismal responses to environmental insults/therapeutic treatments are poorly understood. Using a xenobiotic, we find that permeability of the Drosophila "blood"-brain barrier (BBB) is higher at night. The permeability rhythm is driven by circadian regulation of efflux and depends on a molecular clock in the perineurial glia of the BBB, although efflux transporters are restricted to subperineurial glia (SPG). We show that transmission of circadian signals across the layers requires cyclically expressed gap junctions. Specifically, during nighttime, gap junctions reduce intracellular magnesium ([Mg²⁺]i), a positive regulator of efflux, in SPG

SUBMITTER: Zhang SL 

PROVIDER: S-EPMC5866247 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature