Genome-Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β-Blockers.

ABSTRACT:

Background

For many indications, the negative chronotropic effect of β-blockers is important to their efficacy, yet the heart rate (HR) response to β-blockers varies. Herein, we sought to use a genome-wide association approach to identify novel single nucleotide polymorphisms (SNPs) associated with HR response to β-blockers.

Methods and results

We first performed 4 genome-wide association analyses for HR response to atenolol (a β1-adrenergic receptor blocker) as: (1) monotherapy or (2) add-on therapy, in 426 whites and 273 blacks separately from the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) study. A meta-analysis was then performed between the genome-wide association analysis performed in PEAR atenolol monotherapy and add-on therapy, in each race separa

SUBMITTER: Shahin MH 

PROVIDER: S-EPMC5866313 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature