Monocular enucleation alters retinal waves in the surviving eye.

ABSTRACT:

Background

Activity in neurons drives afferent competition that is critical for the refinement of nascent neural circuits. In ferrets, when an eye is lost in early development, surviving retinogeniculate afferents from the spared eye spread across the thalamus in a manner that is dependent on spontaneous retinal activity. However, how this spontaneous activity, also known as retinal waves, might dynamically regulate afferent terminal targeting remains unknown.

Methods

We recorded retinal waves from retinae ex vivo using multi-electrode arrays. Retinae came from ferrets who were binocular or who had one eye surgically removed at birth. Linear mixed effects models were used to investigate the effects of early monocular enucleation on retinal wave activity.

Results

When

SUBMITTER: Failor SW 

PROVIDER: S-EPMC5866508 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature