Biomarkers of endothelial dysfunction predict sepsis mortality in young infants: a matched case-control study.

ABSTRACT: BACKGROUND:Reducing death due to neonatal sepsis is a global health priority, however there are limited tools to facilitate early recognition and treatment. We hypothesized that measuring circulating biomarkers of endothelial function and integrity (i.e. Angiopoietin-Tie2 axis) would identify young infants with sepsis and predict their clinical outcome. METHODS:We conducted a matched case-control (1:3) study of 98 young infants aged 0-59 days of life presenting to a referral hospital in Bangladesh with suspected sepsis. Plasma levels of Ang-1, Ang-2, sICAM-1, and sVCAM-1 concentrations were measured at admission. The primary outcome was mortality (n = 18); the secondary outcome was bacteremia (n = 10). RESULTS:Ang-2 concentrations at presentation were higher among infants who subsequently

SUBMITTER: Wright JK 

PROVIDER: S-EPMC5866512 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature