Modeling environmentally mediated rotavirus transmission: The role of temperature and hydrologic factors.

ABSTRACT: Rotavirus is considered a directly transmitted disease due to its high infectivity. Environmental pathways have, therefore, largely been ignored. Rotavirus, however, persists in water sources, and both its surface water concentrations and infection incidence vary with temperature. Here, we examine the potential for waterborne rotavirus transmission. We use a mechanistic model that incorporates both direct and waterborne transmission pathways, coupled with a hydrological model, and we simulate rotavirus transmission between two communities with interconnected water sources. To parameterize temperature dependency, we estimated temperature-dependent decay rates in water through a meta-analysis. Our meta-analysis suggests that rotavirus decay rates are positively associated with temperature (<

SUBMITTER: Kraay ANM 

PROVIDER: S-EPMC5866583 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature