Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases.

ABSTRACT:

Introduction

Comparative transcriptome analyses in Alzheimer's disease (AD) and other neurodegenerative proteinopathies can uncover both shared and distinct disease pathways.

Methods

We analyzed 940 brain transcriptomes including patients with AD, progressive supranuclear palsy (PSP; a primary tauopathy), and control subjects.

Results

We identified transcriptional coexpression networks implicated in myelination, which were lower in PSP temporal cortex (TCX) compared with AD. Some of these associations were retained even after adjustments for brain cell population changes. These TCX myelination network structures were preserved in cerebellum but they were not differentially expressed in cerebellum between AD and PSP. Myelination networks were downregulated in both AD a

SUBMITTER: Allen M 

PROVIDER: S-EPMC5866744 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature