In vitro biotransformation of pyrrolizidine alkaloids in different species. Part I: Microsomal degradation.

ABSTRACT: Pyrrolizidine alkaloids (PA) are secondary metabolites of certain flowering plants. The ingestion of PAs may result in acute and chronic effects in man and livestock with hepatotoxicity, mutagenicity, and carcinogenicity being identified as predominant effects. Several hundred PAs sharing the diol pyrrolizidine as a core structure are formed by plants. Although many congeners may cause adverse effects, differences in the toxic potency have been detected in animal tests. It is generally accepted that PAs themselves are biologically and toxicologically inactive and require metabolic activation. Consequently, a strong relationship between activating metabolism and toxicity can be expected. Concerning PA susceptibility, marked differences between species were reported with a comparatively high

SUBMITTER: Kolrep F 

PROVIDER: S-EPMC5866832 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature