Metabolic profiling of murine plasma reveals eicosapentaenoic acid metabolites protecting against endothelial activation and atherosclerosis.

ABSTRACT:

Background and purpose

Atherosclerosis results from a maladaptive inflammatory response initiated by the intramural retention of LDL in susceptible areas of the arterial vasculature. The ω-3 polyunsaturated fatty acids (ω-3) have protective effects in atherosclerosis; however, their molecular mechanism is still largely unknown. The present study used a metabolomic approach to reveal the atheroprotective metabolites of ω-3 and investigate the underlying mechanisms.

Experimental approach

We evaluated the development of atherosclerosis in LDL receptor-deficient mice (LDLR^-/- ) fed a Western-type diet (WTD) plus ω-3 and also LDLR^-/- and fat-1 transgenic (LDLR^-/- -fat-1^tg ) mice fed a WTD. The profiles of ω-3 in the plasma were screened

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5866973 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature