Multiple targets for flecainide action: implications for cardiac arrhythmogenesis.

ABSTRACT: Flecainide suppresses cardiac tachyarrhythmias including paroxysmal atrial fibrillation, supraventricular tachycardia and arrhythmic long QT syndromes (LQTS), as well as the Ca²⁺ -mediated, catecholaminergic polymorphic ventricular tachycardia (CPVT). However, flecainide can also exert pro-arrhythmic effects most notably following myocardial infarction and when used to diagnose Brugada syndrome (BrS). These divergent actions result from its physiological and pharmacological actions at multiple, interacting levels of cellular organization. These were studied in murine genetic models with modified Na_v channel or intracellular ryanodine receptor (RyR2)-Ca²⁺ channel function. Flecainide accesses its transmembrane Na_v 1.5 channel binding site during a

SUBMITTER: Salvage SC 

PROVIDER: S-EPMC5866987 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature