Photoinduced Rapid Transformation from Au Nanoagglomerates to Drug-Conjugated Au Nanovesicles.

ABSTRACT: Gold (Au) agglomerates (AGs) are reassembled using Triton X-100 (T) and doxorubicin (D) dissolved in ethanol under 185 nm photoirradiation to form TAuD nanovesicles (NVs) under ambient gas flow conditions. The positively charged Au particles are then electrostatically conjugated with the anionic chains of TD components via a flowing drop (FD) reaction. Photoirradiation of the droplets in a tubular reactor continues the photophysicochemical reactions, resulting in the reassembly of Au AGs and TD into TAuD NVs. The fabricated NVs are electrostatically collected onto a polished aluminum rod in a single-pass configuration. The dispersion of NVs is employed for bioassays to confirm uptake by cells and accumulation in tumors. The chemo-photothermal activity is determined both in vitro and in viv

SUBMITTER: Poudel BK 

PROVIDER: S-EPMC5867042 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature