Periodically Self-Pulsating Microcapsule as Programmed Microseparator via ATP-Regulated Energy Dissipation.

ABSTRACT: Living systems can experience time-dependent dynamic self-assembly for periodic, adaptive behavior via energy dissipation pathway. Creating in vitro mimics is a daunting mission. Here a "living" giant vesicle system that can perform a periodic pulsating motion using adenosine-5'-triphosphate (ATP)-fuelled dissipative self-assembly is described. This dynamic system is built on transient supramolecular interactions between the polymer and cellular energy currency ATP. The vesicles capturing ATPs will deviate away from equilibrium, leading to an energy ascent that drives a continuous vesicular expansion, until a competitive ATP hydrolysis predominates to break the ATP-polymer interactions and deplete the energy stored in the vesicles, leading to an opposing vesicular contraction. The input of

SUBMITTER: Hao X 

PROVIDER: S-EPMC5867064 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature