Association between antidepressant medication use and epithelial ovarian cancer risk: a systematic review and meta-analysis of observational studies.

ABSTRACT:

Aim

The aim of this paper is to clarify the inconsistent findings in the association between antidepressant use and the risk of epithelial ovarian cancer (EOC).

Methods

This study is a meta-analysis of observational studies retrieved from the PubMed, EMBASE, and Web of Science databases prior to August 15, 2017. Two researchers independently screened studies and extracted study characteristics and risk estimates. The odds ratios (OR) and 95% confidence intervals (CI) of EOC risk were summarized using an inverse variance weighted random-effects model. Heterogeneity between studies was assessed with the I² statistic.

Results

Eight case-control studies involving 7878 EOC cases and 73 913 controls were identified. Compared with non-use, use of antidepressants w

SUBMITTER: Huo YL 

PROVIDER: S-EPMC5867152 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature