Childhood stress, grown-up brain networks: corticolimbic correlates of threat-related early life stress and adult stress response.

ABSTRACT:

Background

Exposure to threat-related early life stress (ELS) has been related to vulnerability for stress-related disorders in adulthood, putatively via disrupted corticolimbic circuits involved in stress response and regulation. However, previous research on ELS has not examined both the intrinsic strength and flexibility of corticolimbic circuits, which may be particularly important for adaptive stress responding, or associations between these dimensions of corticolimbic dysfunction and acute stress response in adulthood.

Methods

Seventy unmedicated women varying in history of threat-related ELS completed a functional magnetic resonance imaging scan to evaluate voxelwise static (overall) and dynamic (variability over a series of sliding windows) resting-state functional c

SUBMITTER: Kaiser RH 

PROVIDER: S-EPMC5867194 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature