Personal history of proliferative breast disease with atypia and risk of multifocal breast cancer.

ABSTRACT: BACKGROUND:A history of proliferative breast disease with atypia (PBDA) may be indicative of an increased risk not just of breast cancer but also of a more aggressive form of breast cancer. METHODS:Multifocal breast cancer (MFBC), defined as 2 or more tumors in the same breast upon a diagnosis of cancer, is associated with a poorer prognosis than unifocal (single-tumor) breast cancer. PBDA, including atypical ductal hyperplasia and atypical lobular hyperplasia, is a known risk factor for breast cancer. Using New Hampshire Mammography Network data collected for 3567 women diagnosed with incident breast cancer from 2004 to 2014, this study assessed the risk of MFBC associated with a previous diagnosis of PBDA. RESULTS:Women with a history of PBDA were found to be twice as likely to be subseq

SUBMITTER: Nutter EL 

PROVIDER: S-EPMC5867212 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature