Biomaterials-Based Approaches to Tumor Spheroid and Organoid Modeling.

ABSTRACT: Evolving understanding of structural and biological complexity of tumors has stimulated development of physiologically relevant tumor models for cancer research and drug discovery. A major motivation for developing new tumor models is to recreate the 3D environment of tumors and context-mediated functional regulation of cancer cells. Such models overcome many limitations of standard monolayer cancer cell cultures. Under defined culture conditions, cancer cells self-assemble into 3D constructs known as spheroids. Additionally, cancer cells may recapitulate steps in embryonic development to self-organize into 3D cultures known as organoids. Importantly, spheroids and organoids reproduce morphology and biologic properties of tumors, providing valuable new tools for research, drug discovery, a

SUBMITTER: Thakuri PS 

PROVIDER: S-EPMC5867257 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature