Daytime Variation in Serum Progesterone During the Mid-Luteal Phase in Women Undergoing In Vitro Fertilization Treatment.

ABSTRACT:

Objective

To investigate whether mid-luteal serum progesterone (P₄) exhibits significant fluctuations during a 12-h daytime period in women undergoing in vitro fertilization (IVF) and to explore whether the extent of these fluctuations could impact the interpretation of luteal progesterone levels in a clinical setting.

Design

Explorative pilot study.

Setting

Public hospital-based fertility unit.

Patients

Ten women undergoing IVF treatment.

Intervention

Seven days after oocyte pick-up, patients underwent frequent repeated blood sampling (every 60 min for 12 h and during two of these hours, every 15 min). Serum samples were analyzed for progesterone, estradiol, and luteinizing hormone (LH).

Main outcome measures

Daytime fluctuation

SUBMITTER: Thomsen LH 

PROVIDER: S-EPMC5867298 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature