Association of complement receptor 1 gene polymorphisms with cognitive function.

ABSTRACT: Previous evidence suggest involvement of the complement receptor 1 (CR1) in development of Alzheimer's disease. We investigated the association of CR1 gene polymorphisms with cognitive function in older subjects. Single nucleotide polymorphisms (SNPs) within the CR1 region on chromosome 1 ( n = 73) were assessed in 5,244 participants in the PROspective Study of Pravastatin in the Elderly at Risk (51.9% female, mean age 75.3 yr). Linear regression, adjusted for age, sex, country, and use of pravastatin, was used to assess the association between the SNPs and cognitive function. All 73 SNPs within the genomic region of the CR1 gene on chromosome 1 were extracted. Eighteen were independent, according to a relatively stringent R² threshold of >0.8 with LDlink. Twelve of the 18 inves

SUBMITTER: Zijlstra LE 

PROVIDER: S-EPMC5867616 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature