Endothelial transcriptomics reveals activation of fibrosis-related pathways in hypertension.

ABSTRACT: Hypertension poses a significant challenge to vasculature homeostasis and stands as the most common cardiovascular disease in the world. Its effects are especially profound on endothelial cells that form the inner lining of the vasculature and are directly exposed to the effects of excess pressure. Here, we characterize the in vivo transcriptomic response of cardiac endothelial cells to hypertension by rapidly isolating these cells from the spontaneous hypertension mouse model BPH/2J and its normotensive BPN/3J control strain and performing and RNA sequencing on both. Comparison of transcriptional differences between these groups reveals statistically significant changes in cellular pathways consistent with cardiac fibrosis found in hypertensive animals. Importantly, many of the fibrosis-l

SUBMITTER: Nelson JW 

PROVIDER: S-EPMC5867617 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature