Microginins from a Microcystis sp. Bloom Material Collected from the Kishon Reservoir, Israel.

ABSTRACT: During blooms, cyanobacteria produce diverse modified peptides. Among these are the microginins, which inhibit zinc-containing metalloproteases. Ten microginins, microginins KR767 (1), KR801(2), KR835 (3), KR785 (4), KR604 (5), KR638 (6), KR781 (7), KR815 (8), FR3 (9), and FR4 (10), were isolated from the extract of a bloom material of Microcystis sp. (IL-405) collected from the Kishon Reservoir, Israel in the fall of 2009. The structures of the pure compounds were elucidated using 1D and 2D NMR techniques and high-resolution mass spectrometry. The absolute configuration of the chiral centers of the amino acids were determined by Marfey's and advance Marfey's methods and by comparison of ¹H and 13C NMR chemical shifts of the Ahda derivatives with those of known microginins. These microgini

SUBMITTER: Lodin-Friedman A 

PROVIDER: S-EPMC5867622 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature