The cellular chloride channels CLIC1 and CLIC4 contribute to virus-mediated cell motility.

ABSTRACT: Ion channels regulate many aspects of cell physiology, including cell proliferation, motility, and migration, and aberrant expression and activity of ion channels is associated with various stages of tumor development, with K⁺ and Cl^- channels now being considered the most active during tumorigenesis. Accordingly, emerging in vitro and preclinical studies have revealed that pharmacological manipulation of ion channel activity offers protection against several cancers. Merkel cell polyomavirus (MCPyV) is a major cause of Merkel cell carcinoma (MCC), primarily because of the expression of two early regulatory proteins termed small and large tumor antigens (ST and LT, respectively). Several molecular mechanisms have been attributed to MCPyV-mediated cancer formati

SUBMITTER: Stakaityte G 

PROVIDER: S-EPMC5868249 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature