S-Glutathionylation of estrogen receptor α affects dendritic cell function.

ABSTRACT: Glutathione S-transferase Pi (GSTP) is a thiolase that catalyzes the addition of glutathione (GSH) to receptive cysteines in target proteins, producing an S-glutathionylated residue. Accordingly, previous studies have reported that S-glutathionylation is constitutively decreased in cells from mice lacking GSTP (Gstp1/p2^-/-). Here, we found that bone marrow-derived dendritic cells (BMDDCs) from Gstp1/p2^-/- mice have proliferation rates that are greater than those in their WT counterparts (Gstp1/p2^+/+). Moreover, Gstp1/p2^-/- BMDDCs had increased reactive oxygen species (ROS) levels and decreased GSH:glutathione disulfide (GSSG) ratios. Estrogen receptor α (ERα) is linked t

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5868252 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature