The complex genetics of human insulin-like growth factor 2 are not reflected in public databases.

ABSTRACT: Recent advances in genetics present unique opportunities for enhancing knowledge about human physiology and disease susceptibility. Understanding this information at the individual gene level is challenging and requires extracting, collating, and interpreting data from a variety of public gene repositories. Here, I illustrate this challenge by analyzing the gene for human insulin-like growth factor 2 (IGF2) through the lens of several databases. IGF2, a 67-amino acid secreted peptide, is essential for normal prenatal growth and is involved in other physiological and pathophysiological processes in humans. Surprisingly, none of the genetic databases accurately described or completely delineated human IGF2 gene structure or transcript expression, even though all relevant inform

SUBMITTER: Rotwein P 

PROVIDER: S-EPMC5868277 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature