Building ProteomeTools based on a complete synthetic human proteome.

ABSTRACT: We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography-tandem mass spectrometry analysis of >330,000 synthetic tryptic peptides representing essentially all canonical human gene products, and we exemplify the utility of these data in several applications. The resource (available at http://www.proteometools.org) will be extended to >1 million peptides, and all data will be shared with the community via ProteomicsDB and ProteomeXchange.

SUBMITTER: Zolg DP 

PROVIDER: S-EPMC5868332 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature