Lymphocytes Contribute to the Pathophysiology of Neonatal Brain Injury.

ABSTRACT:

Background

Periventricular leukomalacia (PVL) is the most common form of preterm brain injury affecting the cerebral white matter. This type of injury involves a multiphase process and is induced by many factors, including hypoxia-ischemia (HI) and infection. Previous studies have suggested that lymphocytes play a significant role in the pathogenesis of brain injury, and the aim of this study was to determine the contribution of lymphocyte subsets to preterm brain injury.

Methods

Immunohistochemistry on brain sections from neonatal mice was performed to evaluate the extent of brain injury in wild-type and T cell and B cell-deficient neonatal mice (Rag1^-/- mice) using a mouse model of HI-induced preterm brain injury. Flow cytometry was performed to determine

SUBMITTER: Nazmi A 

PROVIDER: S-EPMC5868390 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature