Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.

ABSTRACT:

Context

Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability.

Objective

To investigate the genetic regulation of serum E2 and E1 in men.

Design, setting, and participants

Genome-wide association study in 11,097 men of European origin from nine epidemiological cohorts.

Main outcome measures

Genetic determinants of serum E2 and E1 levels.

Results

Variants in/near CYP19A1 demonstrated the strongest evidence for association with E2, resolving to three independent signals. Two additional independent signals were found on the X chromosome; FAMily with sequence similarity 9, member B (FAM9B), rs5934505 (P = 3.4 × 10-8) and Xq27.3, rs5951794 (P = 3.1 × 10-10). E1 signals were found in CYP19A1 (rs2899472, P = 5.5 × 10-23), in Tripartite m

SUBMITTER: Eriksson AL 

PROVIDER: S-EPMC5868407 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature