Ontology highlight
ABSTRACT:
SUBMITTER: Kim JG
PROVIDER: S-EPMC5868421 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Cell reports 20150924 1
The hypothalamus has been implicated in skeletal metabolism. Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affect AgRP neuronal circuit integrity. We found that mice with Ucp2 gene deletion, in which AgRP neuronal function was impaired, were osteopenic. This phenotype was rescued by cell-selective reactivation of Ucp2 in AgRP neurons. When the AgRP circuitry was impaired by early postnatal deletion of AgRP neurons or ...[more]