L61H46 shows potent efficacy against human pancreatic cancer through inhibiting STAT3 pathway.

ABSTRACT:

Background

Pancreatic cancer is the fourth leading cause of cancer-related death worldwide. The poor prognosis of this disease highlights the urgent need to develop more effective therapies. Activation of the STAT3 represents a potential drug target for pancreatic cancer therapy. Currently, clinically available small-molecule inhibitors targeting STAT3 are lacking.

Methods

Through bioassay screening and molecular docking, we identified a small molecule L61H46 that can potently target constitutive STAT3 signaling and kill human pancreatic cancer cells in vitro and in vivo.

Results

L61H46 effectively reduced colony formation and the viability of pancreatic cancer cells in a dose-dependent manner with half-maximal inhibitory concentration (IC₅₀) values in the

SUBMITTER: Bai E 

PROVIDER: S-EPMC5868586 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature