Surfactin-based nanoparticles loaded with doxorubicin to overcome multidrug resistance in cancers.

ABSTRACT:

Background

Multidrug resistance (MDR) is one of the major obstacles to successful cancer chemotherapy. Developing efficient strategies to reverse MDR remains a major challenge. Surfactin (SUR), a cyclic lipopeptide biosurfactant, has been found to display anticancer activity.

Methods

In this paper, SUR was assembled by solvent-emulsion method to load the anticancer drug doxorubicin (DOX). The cytotoxicity of DOX-loaded SUR nanoparticles (DOX@SUR) against DOX-resistant human breast cancer MCF-7/ADR is measured by MTT assay. The cellular uptake and intracellular retention of DOX@SUR are determined by flow cytometry. The tumor accumulation and anticancer activity of DOX@SUR are evaluated in MCF-7/ADR-bearing nude mice.

Results

DOX@SUR induce stronger cytotoxicity against

SUBMITTER: Huang W 

PROVIDER: S-EPMC5868599 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature